| Time CDT | |||
| 09/01 | Akron | Canceled - Weather | |
| 09/08 | Colorado | L 28 - 33 | |
| 09/15 | Troy | L 19 - 24 | |
| 09/22 | @ Michigan | L 10 - 56 | |
| 09/29 | Purdue | L 28 - 42 | |
| 10/06 | @ Wisconsin | L 24 - 41 | |
| 10/13 | @ Northwestern | L 31 - 34 OT | |
| 10/20 | Minnesota | W 53 - 28 | |
| 10/27 | Bethune-Cookman | W 45 - 9 | |
| 11/03 | @ Ohio State | L 31 - 36 | |
| 11/10 | Illinois | W 54 - 35 | |
| 11/17 | Michigan State | W 9 - 6 | |
| 11/23 Friday | @ Iowa | L 28 - 31 | |