| Time CDT | |||
| 10/24 | @ Ohio State | L 17 - 52 | |
| 10/31 | Wisconsin | Canceled by COVID | |
| 11/07 | @ Northwestern | L 13 - 21 | |
| 11/14 | Penn State | W 30 - 23 | |
| 11/21 | Illinois | L 23 - 41 | |
| 11/27 Friday | @ Iowa | L 20 - 26 | |
| 12/05 | @ Purdue | W 37 - 27 | |
| 12/12 | Minnesota | L 17 - 24 | |
| 12/18 Friday | @ Rutgers | W 28 - 21 | |